Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 100 MG
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. Relamorelin TFA has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist.
- Ki of 0.42 nM for GHS-1a receptor.
- Centrally penetrant.
- Increases growth hormone levels.
- Accelerates gastric emptying.
- Potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.
- Purity: 99.81%.
Medchemexpress LLC MM-401 TFA | 1442106-11-7 | 99.3% | 700.75 | 1 MG
MM-401 (TFA) is an MLL1 H3K4 methyltransferase inhibitor. It inhibits MLL1 activity with an IC50 of 0.32 μM by blocking the MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis, and differentiation and can be used for research into MLL leukemia.
- Target specificity: Inhibits MLL1 H3K4 methyltransferase activity by blocking MLL1-WDR5 interaction.
- Potency: Inhibits MLL1 activity with an IC50 of 0.32 μM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM.
- Cellular effects: Induces cell cycle arrest, apoptosis, and differentiation.
- Research application: Useful for research of MLL leukemia.
- Purity: 99.34%.
Medchemexpress LLC Ant308 (TFA) | 99.6% | 3467.10 (free base) | 1 MG
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist that significantly enhances the activation and proliferation of T cells. It inhibits the migration and metastasis and induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling. This compound reduces the expression of MCAM and N-cadherin, making it suitable for studies on acute myeloid leukemia (AML) and uveal melanoma (UVM).
- Vasoactive intestinal polypeptide (VIP receptor) antagonist
- Enhances T cell activation and proliferation
- Inhibits migration and metastasis of melanoma cells
- Induces apoptosis in melanoma tumor cells
- Inhibits VIP-VPAC2 signaling
- Reduces MCAM and N-cadherin expression
- Useful for acute myeloid leukemia (AML) research
- Useful for uveal melanoma (UVM) research
Medchemexpress LLC TFLLR-NH2(TFA) | 1313730-19-6 | 99.6% | 761.83 | 25 MG
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. It stimulates concentration-dependent increases in [Ca2+]i, upregulates E-cadherin, and downregulates vimentin expression in SW620 cells. It also induces a dose-dependent increase of secreted TGF-β1 in activated platelets. In vivo, it causes marked and sustained oedema and Evans blue extravasation, and produces contraction and relaxation in rat duodenal smooth muscle.
- Selective PAR1 agonist with an EC50 of 1.9 μM
- Appears as a white to off-white solid
- Soluble in DMSO and H2O at 100 mg/mL
- Upregulates E-cadherin and downregulates vimentin expression
- Induces dose-dependent increase of secreted TGF-β1
- Stimulates oedema and Evans blue extravasation in vivo
- Produces contraction and relaxation in rat duodenal smooth muscle
Medchemexpress LLC LLVK TFA | 585.66 | 25 MG
LLVK TFA is a selective IκB phosphorylation inhibitor. It reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). LLVK TFA is promising for research of inflammatory bowel disease and rheumatoid arthritis.
- Selective IκB phosphorylation inhibitor
- Reduces LPS-induced pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
- Promising for research of inflammatory bowel disease
- Promising for research of rheumatoid arthritis
Medchemexpress LLC C-telopeptide TFA | 868.89 (free base) | 25 MG
C-telopeptide TFA is a cross-linked peptide of type I collagen. It is released during bone resorption and has been correlated with bone mineral density (BMD). This product is intended for research use only.
- Cross-linked peptide of type I collagen
- Released during bone resorption
- Correlated with bone mineral density (BMD)
- Sequence: Glu-Lys-Ala-His-Asp-Gly-Gly-Arg
- Target: MMP
- Pathway: Metabolic Enzyme/Protease
Medchemexpress LLC Angiopeptin TFA | 2478421-60-0 | 99.01% | 1326.39 | 25 MG
Angiopeptin TFA is a cyclic octapeptide analogue of somatostatin. It acts as a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. It is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA also inhibits adenylate cyclase or stimulates extracellular acidification, making it valuable for research in coronary atherosclerosis.
- Acts as a partial agonist on the release of tritium on CHO hsst2 cells (in vitro).
- Significantly inhibits neointimal formation (in vivo).
- Significantly inhibits coronary artery myointimal proliferation in cardiac allografts (in vivo).
Medchemexpress LLC Apstatin trifluoroacetate | 99.4% | 573.56 g/mol | C25H34F3N5O7 | 5 MG
Apstatin TFA is the trifluoroacetate salt of apstatin, a potent aminopeptidase P (APP) inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human). It has been used in preclinical studies showing cardioprotective effects and is supplied as a solid research compound for biochemical and pharmacological applications.
- Potent aminopeptidase P inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human).
- Demonstrated cardioprotective effects in preclinical studies.
- Supplied as a solid with reported purity of 99.43%.
- Molecular formula C25H34F3N5O7 and molecular weight 573.56 g/mol.
- Recommended storage: powder -80°C (2 years) or -20°C (1 year); protect from moisture.
- Available in small research pack sizes suitable for preclinical experiments.
Medchemexpress LLC Charybdotoxin (TFA) | 96.8% | 4295.89 (free acid) | 500 UG
Charybdotoxin (TFA) is a research-grade peptide supplied as a white to off-white solid. It has a molecular weight of 4295.89 (free acid) and a purity of 96.8% as determined by LCMS. This substance is intended for laboratory use and substance manufacturing, offering stability under recommended storage conditions.
- Supplied as a white to off-white solid
- Purity of 96.8% (LCMS)
- Molecular weight of 4295.89 (free acid)
- Suitable for use as laboratory chemical and for substance manufacturing
- Stable under recommended storage conditions
- Store powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC F9170 (TFA) | 99.7% | 1983.3 g/mol | 5 MG
F9170 (TFA) is a laboratory chemical with 99.7% purity and a molecular weight of 1983.3 g/mol. It appears as a solid and is stable under recommended storage conditions. This product is intended for research use only and should be handled by suitably qualified and experienced scientists in appropriate facilities.
- Solid appearance
- Stable under recommended storage conditions
- Store powder at -80°C for up to 2 years or -20°C for up to 1 year
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month (sealed storage, away from moisture)
- Suitable for shipping at room temperature if less than 2 weeks
- Requires handling in areas with appropriate exhaust ventilation
- Keep container tightly sealed in a cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
Medchemexpress LLC GpTx-1 TFA | 1661050-12-9 | 99.6% | 4073.82 | 100 UG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. This compound also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM).
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Selective for NaV1.4 (IC50 = 0.301 μM).
- Selective for NaV1.5 (IC50 = 4.20 μM).
- IC50 for NaV1.3 is 0.0203 μM.
- IC50 for NaV1.8 is 12.2 μM.
Medchemexpress LLC Atwlppr peptide tfa | 98.6% | 954.00 | 5 MG
ATWLPPR Peptide TFA is a heptapeptide that acts as a selective neuropilin-1 inhibitor. It prevents VEGF165 binding to NRP-1 and is utilized in angiogenesis research, showing promise in reducing early retinal damage associated with diabetes.
- Inhibits VEGF165 binding to neuropilin-1 by 82% at 100 μM
- Preserves vascular integrity and reduces oxidative stress in vivo
- May decrease early retinal damage associated with diabetes
- Prevents increase of inflammation-associated proteins in the retina
Medchemexpress LLC CREBtide TFA | 98.7% | 1716.99 (free acid) | 5 MG
CREBtide TFA is a synthetic 13 amino acid peptide, a CREB (cAMP response element binding protein)-like peptide. It functions as a substrate for both Protein Kinase A (PKA) and Protein Kinase C (PKC).
- Solid appearance
- White to off-white color
- Amino acid sequence: Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg
- Reported as a PKA and PKC substrate
- Apparent Km of 3.9 μM for phosphorylation by cAK
- Apparent Km of 2.9 μM for phosphorylation by cGK
Medchemexpress LLC D-GsMTx4 TFA | 99.9% | 4095.84 | 100 UG
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. It inhibits the mechanosensitive ion channel Piezo2, [Ca2+]i elevation, and mTOR and PI3K-Akt signaling pathways. This compound can inhibit mechanical allodynia and thermal hyperalgesia.
- Inhibits the mechanosensitive ion channel Piezo2.
- Inhibits intracellular calcium elevation.
- Inhibits mTOR and PI3K-Akt signaling pathways.
- Can be used in research related to mechanical stress.
- Useful for studies on chronic pain and idiopathic pulmonary fibrosis.