Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 10g | 537709014
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 10g | 537709014
Medchemexpress LLC Qtx125 TFA | 2989537-78-0 | 99.9% | 50MG
Qtx125 TFA | 2989537-78-0 | 99.9% | 50MG
Apexbio Technology LLC 2X HyperFusion High-Fidelity Master Mix 10X1ml
2X HyperFusion High-Fidelity Master Mix provides high fidelity strong amplification capability and faster amplification speed for most PCR applications HyperFusion DNA polymerase is composed of a Pyrococcus-like proofreading polymerase fused with a DNA-binding domain Its unique structure which combines a novel Pyrococcus-like enzyme and a domain enhancing synthesis capability increases fidelity and speed Due to its high fidelity HyperFusion DNA polymerase is an ideal choice for molecular cloning or other downstream applications HyperFusion DNA polymerase is among the DNA polymerases with the highest fidelity having a 50-fold lower error rate compared to Taq DNA polymerase and a 6-fold lower error rate than Pyrococcus Furious DNA polymerase HyperFusion DNA polymerase exhibits 5 to 3 polymerase activity and 3 to 5 exonuclease activity It generates blunt-ended PCR products without A-overhangs The extension rate is approximately 15-30 sec per kb (up to 10 kb in length)
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G
Apexbio Technology LLC Urotensin-II-114-124-human-TFA
Urotensin II (114-124 human) TFA (CAS No 251293-28-4) is a peptide fragment primarily utilized in cardiovascular and neurological research It originates from human urotensin II a potent vasoactive peptide involved in various physiological processes primarily acting through the G protein-coupled urotensin II receptor (UT) This interaction influences cellular pathways related to vasoconstriction and vascular smooth muscle proliferation In vitro this fragment functions in the nanomolar to low micromolar range demonstrating significant potency in cellular assays Typically employed in cell models and animal studies it aids in exploring cardiovascular dysfunction evaluating potential therapeutic agents and drug screening protocols Experimental concentrations typically depend on the specific research design ensuring flexibility for diverse investigative focuses
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G