Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
VWR International Trifluoroacetic acid ≥99.8% | 76-05-1 | MFCD00004169 | 1l
Trifluoroacetic acid ≥99.8% | 76-05-1 | MFCD00004169 | 1l
Medchemexpress LLC Forigerimod trifluoroacetate | 00-00-0 | 99.9% | C117H181N34O32PS·xC2HF3O2 | 5 MG
Forigerimod TFA is a 21-amino-acid peptide fragment supplied as the trifluoroacetate salt. It acts as a CD4 T-cell modulator and has been used in research on autophagy and autoimmune disorders, including systemic lupus erythematosus. Supplied as a powder with high listed purity, it is intended for research use in cellular and immunology studies.
- 21-amino-acid peptide, TFA salt
- High purity suitable for research (listed 99.88%)
- Soluble in DMSO and water at 100 mg/mL with sonication
- Powder storage: -80°C (2 years) or -20°C (1 year)
- In solvent storage: -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC Ceftolozane trifluoroacetate salt | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 25 MG
Ceftolozane TFA is the trifluoroacetate salt of ceftolozane, a cephalosporin-class antibiotic active against Gram-negative bacteria. It is provided for research use in antibacterial studies, assay development, and medicinal chemistry where it can serve as a synthetic intermediate for the design and optimization of novel antibiotic candidates.
- Trifluoroacetate salt form for improved stability and handling.
- Active against Gram-negative bacteria.
- Suitable for medicinal chemistry and synthetic applications.
- Available in small research quantities for assay development.
- Characterized with confirmed purity and molecular weight.
Medchemexpress LLC Ceftolozane TFA | 1628046-32-1 | 98.2% | 780.71 g/mol | C25H31F3N12O10S2 | 1 ML
Ceftolozane TFA is a cephalosporin-class antibiotic supplied as a 10 mM solution in DMSO (1 mL). It is intended for use in antibacterial research, analytical method development, and as a building block for synthesis of novel antibiotics. Trifluoroacetate salt; molecular formula C25H31F3N12O10S2; molecular weight 780.71 g/mol.
- Provided as a ready-to-use 10 mM solution in DMSO.
- Suitable for antibacterial activity assays and analytical method development.
- Useful as a synthetic intermediate and reference standard for research.
- High purity suitable for analytical and preparative applications.
- Supplied in a 1 mL vial for small-scale experiments.
Medchemexpress LLC Apstatin trifluoroacetate | 99.4% | 573.56 g/mol | C25H34F3N5O7 | 5 MG
Apstatin TFA is the trifluoroacetate salt of apstatin, a potent aminopeptidase P (APP) inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human). It has been used in preclinical studies showing cardioprotective effects and is supplied as a solid research compound for biochemical and pharmacological applications.
- Potent aminopeptidase P inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human).
- Demonstrated cardioprotective effects in preclinical studies.
- Supplied as a solid with reported purity of 99.43%.
- Molecular formula C25H34F3N5O7 and molecular weight 573.56 g/mol.
- Recommended storage: powder -80°C (2 years) or -20°C (1 year); protect from moisture.
- Available in small research pack sizes suitable for preclinical experiments.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride ReagentPlus(R), >=99% | 407-25-0 | MFCD00000416 | 4X100G
Trifluoroacetic anhydride ReagentPlus(R), >=99% | Purity: >=99% | Mol Wt: 210.03 | 407-25-0 | MFCD00000416 | 4X100G
Medchemexpress LLC Pf15 TFA | 99.7% | 969.97 | C46H50F3N13O8 | 5 MG
A heterobifunctional PROTAC that recruits cereblon to promote degradation of FLT3-ITD. It reduces FLT3 and STAT5 phosphorylation, inhibits proliferation of FLT3-ITD-positive cells, and shows tumor growth inhibition in preclinical models. Supplied as a trifluoroacetic acid salt for laboratory research.
TARGETMOL CHEMICALS INC CAMIZESTRANT TFA 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Camizestrant TFA (AZD-9833 TFA) is a potent and orally active antagonist of estrogen receptor (ER).